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Image Search Results
Journal: PLoS ONE
Article Title: An Ethanolic Extract of Lindera obtusiloba Stems, YJP-14, Improves Endothelial Dysfunction, Metabolic Parameters and Physical Performance in Diabetic db/db Mice
doi: 10.1371/journal.pone.0065227
Figure Lengend Snippet: (A) Cyclooxygenase-derived vasoactive prostanoids blunt endothelium-dependent relaxations to Ach in aortic rings of the db/+, db/db and db/db+Pio groups but not in the db/db+LOE group. Concentration-dependent relaxations induced by Ach in aortic rings with endothelium in the absence and presence of indomethacin (an inhibitor of cyclooxygenases). Values are shown as means ± S.E.M. (n = 5–7). * P <0.05 indicates a significant difference versus the respective control. (B) LOE inhibits COX-1 and COX-2 activity in vitro in a concentration-dependent manner. Values are shown as means ± S.D. (duplicate determinations).
Article Snippet: To determine the ability of LOE to inhibit COX-1 and/or COX-2 activities, a
Techniques: Derivative Assay, Concentration Assay, Control, Activity Assay, In Vitro